UMC Program in Neuroscience

Faculty

PROFESSORS


	Garth Bissette, Ph.D. (Psychiatry) Professor of Psychiatry & Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-6683 Fax: 601-984-5899 E-mail: gbissette@psychiatry.umsmed.edu
Recent Publications: Horgan J, Miguel-Hidalgo J, Thrasher M, Bissette G. (2007) Longitudinal Brain Corticotropin-Releasing Factor and Somatostatin in a Transgenic Mouse (Tg2576) Model of Alzheimers Disease. Journal of Alzheimers Disease, 12:115-127. Lopez, J, Roffwarg H, Dreher A, Bissette G, Karolewicz B, Shaffery J. (2008) REM sleep deprivation LTP stability and affects some glutamatergic signalling proteins during hippocampal development. Neuroscience (in press).

	Z hengwei Cai, Ph.D. ( Pediatrics) Professor of Pediatrics Associate Professor of Pharmocology & Toxicology The University of Mississippi Medical Center School of Medicine The Department of Pediatrics The Department of Pharmacology & Toxicology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-2786 Fax: 601-815-3666 E-Mail: zcai@ped.umsmed.edu
Research Interests: The major focus of my research is to understand mechanisms involved in brain injury following perinatal hypoxia-ischemia or maternal infection/inflammation. Animal models of periventricular leukomalacia, the most common white matter lesion in very preterm infants, are used in our studies. Recent Publications: Fan, L-W. Mitchell, H.J. Tien, L-T. Zheng, B. Pang, Y. Rhodes, P.G. Cai, Z. 2008 a-phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain. Dev Neurobiol. 68: 365-378. PMID: 18161853. Pang, Y. Zheng, B. Fan, L-W. Rhodes, P.G. Cai, Z. 2007. IGF-1 protects oligodendrocyte progenitors against TNF-a-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Glia, 55: 1099-1107. PMID: 17577243.



	Jerry Farley, Ph.D. (Pharmacology) Professor of Pharmacology & Toxicology The University of Mississippi Medical Center Department of Pharmacology & Toxicology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601 984-1630 FAX: 601-984-1637 E-Mail: jfarley@pharmacology.umsmed.ed

	Elise Gomez-Sanchez, DVM (Medicine) Professor of Medicine The University of Mississippi Medical Center Division Of Endocrinology Research Service Senior Research Physiologist 1500 E. Woodrow Wilson Blvd. Jackson, Mississippi 39216-4505 Phone: 601-368-3844 FAX: 601-364-1236 E-Mail : egomez-Sanchez@umsmed.edu
Research Interests: We study the role of adrenal corticosteroids in the development of hypertension and end organ disease, with a focus on (1) normal and aberrant control of adrenal and extra-adrenal aldosterone synthesis, the latter primarily in the brain, (2) ligand and functional selectivity of mineralocorticoid receptor activity in different tissues, including the brain, and (3) non-genomic actions of aldo. To this end we use multiple disciplines and techniques, including biochemistry, molecular biology, anatomy, histology, physiology, and behavior in cultured cells, preserved tissues and live animals, including transgenic rats and mice. Recent Publications: Bhagat R, Gomez-Sanchez EP, Warden MP, de Rodriguez A, Spurzem J, Dwyer TM, Gomez-Sanchez CE, "Role of Mineralocorticoid Receptor in Paraquat-induced Rat Lung Fibrosis, Proc Am Thorac Soc. 2008 Apr,; 5(3):369. No abstarch Available PMID: 18403358 [PubMed - in process] Yu Y, Wei SG, Zhang ZH, Gomez-Sanchez E, Weiss RM, Felder RB, "Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure?" Hypertension. 2008 Mar;51(3):727-33. Epub 2008 Jan 28. PMID: 18227408 [PubMed - indexed for MEDLINE]

	Duane Haines, Ph.D. (Anatomy) Chairman and Professor of Anatomy The University of Mississippi Medical Center Deparment of Anatomy 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1640 Fax: 601-984-1655 E-mail: dhaines@anatomy.umsmed.edu


	Rick C.S. Lin, Ph.D. (Anatomy) Professor of Anatomy The University of Mississippi Medical Center Department of Anatomy Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1665 FAX: 601-984-1655 E-Mail: rlin@anatomy.umsmed.edu
Research Interests: The major focus of my research is to understand: 1) how sensory information is processed using the rodent trigeminal somatosensory system as our model; and 2) how cortical activity is influenced by ascending inputs from brainstem monoaminergic centers. To address these interests, we use qualitative and quantitative image analysis, as well as multi-neuron recording techniques. Recent Publications: Lin, C.S., Nicolelis, M.A.L., Schneider, J.S. and Chapin, J.K. A major direct GABAergic pathway from zona incerta to neocortex. Science 248:1553-1556, 1990 Nicolelis, M.A.L., Lin, R.C.S., Woodward, D.J. and Chapin, J.K. Peripheral block of ascending cutaneous information induces immediate spatio-temporal changes in thalamic network. Nature 361:533-536, 1993

	Thomas E. Lohmeier, Ph.D. (Physiology & Biophysics) Professor & Director of Physiology & Biophysics The University of Mississippi Medical Center Department of Physiology & Biophysics 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1822 FAX: 601-984-1817 E-Mail: tlohmeier@physiology.umsmed.edu
Research Interests: My research interests include an understanding of neurohormonal mechanisms in the control of renal function and arterial pressure, and especially the role of these mechanisms in mediating hypertension. Recent Publications: Lohmeier, T.E., D.A. Hildebrandt, T.M. Dwyer, A.M. Barrett, E.D. Irwin, M.A. Rossing, R.S. Kieval. Renal denervation does not abolish sustained baroreflex-mediated reductions in arterial pressure. Hypertension 49: 373-379, 2007. Lohmeier, T.E., T. M. Dwyer, E.D. Irwin, M.A. Rossing, R.S. Kieval. Prolonged activation of the baroreflex abolishes obesity-induced hypertension. Hypertension 49: 1307-1314, 2007.

	James Lynch, Ph.D. (Anatomy) Professor of Anatomy The University of Mississippi Medical Center Deparment of Anatomy 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1657, 601-984-1640 Fax: 601-984-1655 E-mail: jclynch@anatomy.umsmed.edu
Research Interests: Research in this laboratory focuses on the functional organization and anatomical connectivity of regions in the cerebral cortex that are concerned with the control of voluntary movement, and specifically with voluntary eye movement. We have used behavioral studies, behavioral neurophysiology studies, and physiologically-guided neuroanotomical studies in non-human primates to determine that there are several distinct regions in the cerebral cortex (designated eye field) that form a cortivo-cortical network that functions cooperatively to guide and execute voluntary, visually guided saccadic and pursuit eye movements. Recent Publications: Lynch, J.C. and Tian, .R. Cortico-cortical networks and cortic-subcortical loops for the higher control of eye movements. In: Progress in Brain Research, Vol 151: Neuroanatomy of the Oculomotor System, ed. J. Buettner-Ennever, Elsevier, New York, pp.461-501, 2006. Lynch, J.C. Anatomical pathways for oculomotor control. In: The New Encyclopedia of Neuroscience, eds. Squire, L., Albright, T., Bloom, F., Gage, F., and Spitzer, N. (In press)

	Paul May, Ph.D. (Anatomy) Professor of Anatomy Professor of Ophthalmology Assistant Professor of Neurology The University of Mississippi Medical Center Department of Anatomy Department of Ophthalmology Department of Neurology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1662, 601-984-1640 FAX: 601-984-1655 E-Mail: pmay@anatomy.umsmed.edu

	Thomas H. Mosley, Jr., Ph.D. (Geriatrics) Associate Director of Geriatric Medicine Professor of Medicine (Geriatrics) The University of Mississippi Medical Center Department of Medicine (Geriatrics) 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-2763 FAX: 601-815-3422 E-Mail: tmosley@medicine.umsmed.edu
Research Interests: Primary interests are in brain aging and broadly include the epidemiology of dementia, epidemiology and clinical outcomes (such as stroke and neurocognitive decline) associated with subclinical changes identified on neuroimaging, and risk factors (including genes) associated with brain aging and dementia. Recent Publications: Ikram, M.A.,et al. (2009). Genomewide association studies of stroke. New England Journal of Medicine, 360(17):1718-1728. Knopman DS, Mosley TH, Catellier DJ, Coker LH for the Atherosclerosis Risk in Communities Study Brain MRI Study (2009). Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study. Alzheimer’s & Dementia; 5(3):207-14.

	George Mychaskiw, D.O., F.A.A.P. (Anesthesiology) Vice Chairmand and Professor of Anesthesiology Anesthesia Clinical Director The University of Mississippi Medical Center Department of Anesthesiology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5900 Fax: 601-984-5959 E-mail: gmychaskiw@anesthesia.umsmed.edu


	Ian A. Paul, Ph.D. (Psychiatry) Director, Neuroscience Scholars Summer Program Director, Graduate Program in Neuroscience Director, CPN Mentoring Core Professor of Psychiatry and Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 Fax: 601-984-5899 E-Mail: ipaul@psychiatry.umsmed.edu
Research Interests: My research focuses on the neurobehavioral effects and mechanisms of antidepressant and other psychiatric pharmacotherapies. I am especially interested in the effects of these drugs on neuronal and behavioral development. Recent Publications: Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S., Paul, I.A. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31:47-57, 2006 (Online publication 6/9/2005). Maciag, D., Williams, L., Coppinger, D. and Paul, I.A. Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. Eur. J. Pharmacol., 532: 265-270, 2006 (Online publication 2/15/2006).

	Grazyna Rajkowska, Ph.D. (Psychiatry) Professor of Psychiatry and Human Behavior Chief, Laboratory Quantitative Neuroanatomy The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 Fax: 601-984-5899 E-Mail: grajkowska@psychiatry.umsmed.edu
Research Interests: Quantitative morphology of prefrontal cortex from postmortem brain tissue of individuals diagnosed with major depression and age-matched healthy controls. In particular, the relationship between alterations in the specific subpopulations of cortical glial and neuronal cells and serotonin and glutamate neurotransmitter systems in depression is examined by using immunohistochemical and molecular techniques. Recent Publications: Rajkowska G, O'Dwyer G, Teleki Z, Stockmeier C, Miguel-Hidalgo JJ (2007). Reduction in calbindin-immunoreactive GABA interneurons in the prefrontal cortex in major depression. Neuropsychopharmacology 32:471-482. Rajkowska, G. and Miguel-Hidalgo, JJ (2007). Gliogenesis and Glial Pathology in Depression. Current Drug targets-CNS and Neurological Disorders. Drug Targets 6:219-233.

	Soundar Regunathan, Ph.D. (Psychiatry) Professor of Psychiatry and Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 Fax: 601-984-5899 E-Mail: sregunathan@psychiatry.umsmed.edu
Research Interests: The major research in my laboratory focuses on novel neruomodulators/ neruotransmitters and their receptors in the regulation of cell death, neruoinflammation and pain processing. The regulation of the synthesis of neuroactive molecules derived from arginine such as nitric oxide and agmatine during neruoinflammation and chronic pain are the main area of investigation. Recent Puiblications: Iyo, A.H., Zhu, M.Y., Ordway, G.A. and Regunathan, S.: Expression of arginine decarboxylase in brain regions and neuronal cells. J. Neurochem. 96: 1042-1050, 2006 Wang, W.P M.D. Iyo,A.H., Miguel-Hidalgo, J., Regunathan, S and Zhu M.Y.: Agmatine Protects against Cell Damage Induced by NMDA and Glutamate in Cultured Hippocampal Neurons. Br. Res. 1084: 210-216 (2006)

	Rob Rockhold, Ph.D. (Pharmacology) Professor of Pharmacology & Toxicology Professor of Health Sciences Assistant Vice Chancellor for Academic Affairs The University of Mississippi Medical Center Department of Pharmacology & Toxicology 2500 N. State Street Jackson, Mississippi 39216-4505 Phone: 601-984-2810 FAX: 601-984-2970 E-Mail:rrockhold@pharmacology.umsmed.edu
Research Interests: Dr. Rockhold currently is active in examination of the toxic effects of venom alkaloids from the red imported fire ant on the cardiovascular and nervous systems. He continues interest in neuropharmacological research examining the basis for narcotic analgesic dependence in rats. Recent Publications: Howell, G., West, L., Jenkins, C., Lineberry, B., Yokum, D. and Rockhold, R. In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine. Biomedcentral Pharmacology 5:13 (18 Aug), 2005 http://www.biomedcentral.com/1471-2210/5/13. Zhu, H., Jordan, J., Hardy, S., Fulcher, B., Childress, C., Varner, C., Windham, B., Jeffcoat, B., Rockhold, R., Zhou, W. Linear acceleration-evoked cardiovascular responses in awake rats. J. Appl. Physiol. 103: 646-54, 2007.

	Craig Stockmeier, Ph.D. (Psychiatry) Professor of Psychiatry & Human Behavior Director, Center for Psychiatric Neuroscience The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience National Center for Research Resources The National Institute of Health 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 FAX: 601-984-5899 E-Mail: cstockmeier@psychiatry.umsmed.edu
Research Interests: Dr. Stockmeier's studies examine disease-specific abnormalities in anatomic, biochemical and pharmacological markers and related gene expression in postmortem brain tissue from subjects with depression. The ultimate goal of these studies is to identify pathophysiological processes that may be critical in the etiology of depression, and thereby target mechanisms in brain against which new therapeutic medications can be directed. Recent Publications: Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, Uylings HBM, Friedman L, Rajkowska G. Cellular Changes in the Postmortem Hippocampus in Major Depression. Biological Psychiatry, 56:640-650, 2004. Stockmeier CA, Ordway GA. Interactions of Norepinephrine with Other Neurotransmitter Systems: Anatomical Basis and Pharmacology. In: Brain Norepinephrine: Neurobiology and Therapeutics, (ed. GA Ordway, MA Schwartz, and A Frazer), Cambridge University Press, Cambridge, pp 53 - 67, 2007.

	Parminder Vig, Ph.D. (Neurology) Professor of Neurology & Biochemistry The University of Mississippi Medical Center Department of Neurology & Biochemistry 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601 984-5513 FAX: 601-984-6626 E-Mail: PVig@neurology.umsmed.edu
Research Interests: To understand molecular mechanisms of nerve cell death in neurodegenerative diseases using transgenic mouse models and cell culture. Recent Publications: M Pande, A Harps, M Sundaram, PJS Vig. Role of nitric oxide in domoic acid induced hippocampal degeneration. J. Neurological Sci. (Free access: Online Publication) 24:16-24 (2007) JR Salameh, LM Talbott, W May, B Gosheh, PJS Vig, DO McDaniel. Role of biomarkers in incisional herias. Am Surg. 73:561-567 (2007)

	William Woolverton, Ph.D. (Psychiatry) Professor of Psychiatry and Human Behavior Vice-Chairman for Research CPN Behavioral Core Leader The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-815-1022 FAX: 601-984-5899 E-Mail: wwoolverton@psychiatry.umsmed.edu
Research Interests: The goal of the Laboratory of Drug Abuse Research is to improve our understanding of the interaction between pharmacological, environmental, and neurochemical variables that control drug abuse. The approach involves combining techniques of in vivo pharmacology with those of behavior analysis to study intravenous self-administration, drug discrimination, and the direct effects of drugs on the behavior of animals. Recent Publications: Woolverton, W.L., Wang, Z., Vasterling, T., Carroll, F.I. and Tallarida, R.: Self-administration of drug mixtures with monkeys: combining drugs with comparable mechanisms of action. Psychopharmacology 196: 575-582, 2008. Woolverton, W.L., Myerson, J. and Green, L.: Delay discounting of cocaine by rhesus monkeys. Exp. Clin. Psychopharm. 15: 238-244, 2007.

	Wu Zhou, Ph.D. (Otolaryngology and Communicative Science) Professor of Otolaryngology and Communicative Science The University of Mississippi Medical Center Department of Otolaryngology and Communicative Science 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5159 Fax: 601-984-1655 E-mail: wzhou@ent.umsmed.edu
ASSOCIATE PROFESSORS
	March Ard, Ph.D. (Anatomy) Director, Graduate Program in Anatomy Associate Professor of Anatomy The University of Mississippi Medical Center Department of Anatomy 2500 North State Street Jackson, MS 39216 Phone: 601-984-1645 Fax: 601-984-1655 Email: mard@anatomy.umsmed.edu
Research Description: I'm interested in glial cells of the central nervous system, particularly in how microglia are involved in Alzheimer's disease. Microglia in amyloid plaques may contribute to plaque deposition and turnover, and microglial immune responses are part of the inflammatory response that occurs in the brain in Alzheimer's disease. We're studying microglial secretion of inflammatory signaling molecules in cell culture using immunocytochemistry, enzyme-linked immunoassay, gel electrophoresis, and electron microscopy. Recent Publications: D'Andrea, M.R., Cole, G.M., and Ard, M.D. 2004 A review of the microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol. Aging 25:675-683. Chen, S., Averett, N.T., Manelli, A., LaDu, M.J., May, W., and Ard, M.D. 2005 Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. Journal of Alzheimer's Disease 7:25-35.
	Mark Austin, Ph.D. (Psychiatry) Director,CPN Molecular Biology Core Associate Professor of Psychiatry and Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5742 FAX: 601-984-5899 E-Mail: maustin@psychiatry.umsmed.edu
Research Description: My research has been focused on investigation the molecular mechanisms that may underlie the deficiency in serotonin neurotransmission in the brain of subjects with major depressive disorder and alcohol dependence. Research projects utilize a variety of biochemical and molecular biological techniques to investigate gene and protein expression of various enzymes, receptors, transporters, neurotrophic factors and novel serotonin-related transcription factors in human postmortem brain specimens. Recent Publications: Bonkale, W.L., Austin, M.C. 3,4-Methylenedioxymethamphetamine (MDMA) induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. 155: 270-276, 2008. Szewczyk, B., Albert, P.R., Burns, A.M., Czesak, M., Overholser, J.C., Jurjus, G.J., Meltzer, H.Y., Konick, L.C., Dieter, L., Herbst, N., May, W., Rajkowska, G., Stockmeier, C.A., Austin, M.C. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int. J. Neuropsychopharmacol. 2008, In press.

	Ranjan Batra, Ph.D. (Anatomy) Associate Professor of Anatomy The University of Mississippi Medical Center Deparment of Anatomy 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1652 Fax: 601-984-1655 E-mail: rbatra@anatomy.umsmed.edu

	Lewis Longtang Chen, Ph.D. (Otolaryngology & Communitcative Sciences) Associate Professor of Otolaryngology & Communicative Sciences 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1682 Fax: 601-815-5377 E-mail: lchen2@ent.umsmed.edu
Research Description: Oculomotor sensory-motor control Recent Publications: Chen LL and Tehovnik EJ (2007) Cortical control of eye and head movements: integration of movements and percepts. Eur J Neurosci. 25:1253-1264. Chen LL (2006) Head movements evoked by electrical stimulation in the frontal eye field of the monkey: evidence for independent eye and head control. J Neurophysiol. 95: 3528-3542. ```````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````
	Heather Drummond, Ph.D. (Physiology) Associate Professor of Physiology & Biophysics The University of Mississippi Medical Center Department of Physiology & Biophysics 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1812 Fax: 601-984-1817 E-MAIL: hdrummond@physiology.umsmed.edu
Research Interests: Our research focuses on how neurons and smooth muscle cells sense mechanical stimuli and how these processes contribute to neurite formation and sensory transduction. Current research has focused on the importance of Degenerin/Epithelial Sodium Channel (DEG/ENaC) proteins as mechanosensitive ion channels in mechanotransduction. Recent Publications: Drummond, HA, M Furtado, S Myers, S Grifoni, K. Parker and D Stec. EnaC proteins are required for NGF-induced neurite growth. Am. J. Physiology-Cell Physiology. 290(2); C404-10, 2006 Jernigan, Nikki L. and Drummond, Heather A. Vascular ENaC proteins are required for renal myogenic construction. Renal 289: 89-901, 2005

	T. David Elkin, Ph.D. (Psychiatry) Associate Professor of Psychiatry & Human Behavior Instructor of Pediatrics The University of Mississippi Medical Center Department of Psychiatry & Human Behavior Department of Pediatrics 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5855 Fax: 601-984-5857 E-mail: delkin@psychiatry.umsmed.edu
Research Interests: My research can be summarized broadly as child clinical, and more specifically as focused on late effects related to treatment in children and adolescents with chronic medical conditions such as cancer, brain tumors, and sickle cell disease. Recent Publications: Stoppelbein, L., Greening, L., Elkin, T.D. Risk of Post-traumatic Stress Symptoms: A Comparison of Pediatric Cancer Survivors and Bereaved Families. Journal of Pediatric Psychology, 31(4), 367-376. 2006 Elkin, T.D., Megason, G., Robinson, A., Bock, H-G, Schrimsher, G., Muenzer, J. Longterm neurocognitive outcome in an adolescent with Hurler-Scheie syndrome. Neuropsychiatric Disease and Treatment, 2(3). (in press)

	J onathan Fratkin, M.D. (Pathology) Associate Professor of Pathology The University of Mississippi Medical Center Department of Pathology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1885 Fax: 601-984-1531 E-Mail: jfratkin@pathology.umsmed.edu


	Anna Lerant, M.D. (Anesthesiology) Associate Professor of Anesthesiology Associate Director, Medical Advanced Skill and Simulation Center The University of Mississippi Medical Center Department of Anesthesiology 2500 North State Street CW100-2 Jackson, Mississippi 39216-4505 Phone: 601-815-7485 FAX: 601-815-9182 E-Mail: alerant@anesthesiology.umsmed.edu
Recent Publications: Phillips, WJ, Keith, J., Lerant A., Jackson-Williams, L.: Handbook of Acute Pain Management and Procedural Sedation. 2008 Mosby Elsevier ISBN-13: 978-03230533374 Phillips WJ, Gadiraju S, Dickey S, Galli R, Lerant AA: Dexmedetomidine relieves pain associated with acute sickle cell crisis. J Pain Symptom. Management 2007; 34: 346-9

	Jeffrey Love, B.S., Ph.D. Associate Professor of Pharmacology & Toxicology The University of Mississippi Medical Center Department of Pharmacology & Toxicology Unviersity of Mississippi Medical Center 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1621 Fax: 601-984-1637 E-Mail: jlove@pharmacology.umsmed.edu
Research Description: Our lab studies the regulation of pancreatic exocrine and endocrine secretion by the autonomic nervous system. The work focuses on the regulatioin of ganglionic and neuroeffector synaptic transmission of single pancreatic (parasympathetic) neurons. Recent Publications: Yi, E., and Love, J.A. Short-term synaptic plasticity in rabbit pancreatic ganglia. Autonomic Neuroscience.: Basic and Clinical 119:36-47, 2005. Yi, E., and Love, J.A. Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia. Autonomic Neuroscience: Basic and Clinical 122:45-57, 2005.

	Jim Shaffery, D.Phil. (Psychiatry) Associate Professor of Psychiatry and Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-6684 FAX: 601-984-5899 E-Mail: jshaffery@psychiatry.umsmed.edu
Research Interests: The rapid eye-movement sleep state appears to be necessary for proper brain maturation. Research in the Animal Sleep Laboratory is aimed at working out the neurophysiological and biochemical mechanisms means by which this sleep state contributes to early life maturation of the central nervous system. Recent Publications: Shaffery J.P., Sinton CM, Bisette G, Roffwarg HP, and Marks GP. Rapid Eye Sleep Deprivation Modifies expression of Long-Term Potentiation in Visual Cortex of Immature Rats Neuroscience 110 (3): 431-443 2002 J.P. Shaffery, Jorge Lopez, Garth Bissette, Howard P. Roffwarg. Rapid eye movement sleep Deprivation in post-critical period, adolescent rats alters the balance between inhibitory and excitatory mechanisms in visual cortex. Neuroscience Letters 393 (2-3):131-135 2006

	Kimberly Simpson, Ph.D. (Anatomy) Associate Professor of Anatomy The University of Mississippi Medical Center Department of Anatomy Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1644 FAX: 601-984-1655 E-Mail: ksimpson@anatomy.umsmed.edu
Research Description: The Focus of my laboratory is to understand how neuromodulatory systems, such as the locus coeruleus-norepinephrine system and dorsal raphe-serotonin system, are functionally organized. We utilize sophisticated tract tracing, electron microscopic, immunohistochemical, and electrophysiological approaches to: 1) elucidate neuronal interactions and mechanisms important in transmitter regulation, and 2) further understand the cellular basis of behavioral disorders such as depression. Recent Publications: Maciag D, Simpson KL, Coppinger D., Lu Y, Wang Y, Lin RCS, Paul IA. (2006) Neonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry. Neuropsychopharmacolgy; 31:47-57. Simpson KL, Waterhouse BD, Lin RCS (2006). Characterization of Neurochemically Specific Projections from the Locus Coeruleus with respect to Somatosensory-related Barrels. Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology; 288:166-73

	Susan Warren, Ph.D. (Anatomy) Associate Professor of Anatomy The University of Mississippi Medical Center Department of Anatomy 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1671, 601-984-1640 FAX: 601-984-1655 E-Mail: swarren@anatomy.umsmed.edu
Research Interests: Employing a multi-disciplinary approach including anatomical and physiological techniques, the lab focuses on the neurobiology of the somatosensory system and coding of spatiotemporal information in various centers throughout the tactile system. A second focus is directed at the neurobiology of the oculomotor system, specifically the role of brain circuits producing blink reflexes, as well as brain centers and circuits controlling head and eye movements associated with gaze changes. Recent Publications: Warren, S, Waitzman, DM, and May, PJ (2008) Anatomical Evidence for Interconnections Between Central Mesencephalic Reticular Formation and Cervical Spinal Cord in the Cat and Macaque. Anatomical Record, 291:141-160 Zhou, L, Warren, S, and May, PJ (2008) The Feedback Circuit Connecting the Central Mesencephalic Reticular Formation and the Superior Colliculous in the Macaque Monkey: Tectal Connections. Exp. Brain Research (Submitted)

	Hong Zhu, M.D., Ph.D. ( Otolaryngology) Associate Professor of Otolaryngology and Cummunicative Sciences The University of Mississippi Medical Center Department of Otolaryngology and Cummunicative Sciences 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-815-3098 Fax: 601-815-5085 E-Mail: hozhu@ent.umsmed.edu
Research Description: The research in laboratory focuses on 1) neurobiolgy of opioids abuse; 2) neurophysiology and neurospharmacolgy of vestibular system, specifically the vestibular-cardiovascular reflex. The approach includes in vivo multi-electrode single unit recordings, in vivo voltammetry, and behavioral testing. Recent Publications: Zhu H, Jordan JR, Hardy SPG, Fulcher B, Childress C, Varner C, Windham B, Jeffcoat B, Rockhold RW and Zhou W. Linear acceleration-evoked cardiovascular responses in awake rats. J Appl Physiol 103: 646-654, 2007. Zhu, H. and Zhou, W. Excitatory amino acid receptors are involved in the morphine-induced synchronous oscillatory discharges in the locus coeruleus. Eur. J. Pharmacol. 528:73-78, 2005.
ASSISTANT PROFESSORS
	Charles Bishop, AuD (Otolaryngology and Communicative Science) Assistant Professor/Audiologist The University of Mississippi Medical Center Deparment of Otolaryngology and Communicative Science 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5160 Fax: E-mail: cebishop@ent.umsmed.edu

	Laree Hiser, Ph.D. (School of Nursing) Assistant Professor of Nursing The University of Mississippi Medical Center School of Nursing 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-6247 Fax: 601-984-6206 E:Mail: lmhiser@son.umsmed.edu
Research Interests: The mechanism behind the clinical manifestations of multiple sclerosis is the primary research focus of my laboratory. We also study neuroprotective mechanisms that are directly applicable to other diseases. Recent Publications: Cucchiarelli, V., Hiser, L., Smith, H., Frankfurter, A., Spano, A., Correia, J. J., & Lobert, S. (2008). Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas. Cell Motility and the Cytoskeleton, 65, 675-85. Hiser, L., Herrington, B., & Lobert, S. (2008). Effect of noscapine and vincristine combination on demyelination and cell proliferation in vitro. Leukemia and Lymphoma, in press.

	Abiye Iyo, Ph.D. (Psychiatry) Professor of Psychiatry The University of Mississippi Medical Center Department of Psychiatry 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-815-5619 Fax: 601-984-5899 E-mail: aiyo@psychiatry.umsmed.edu
Research Interests: Recent Publications: Iyo AH, Zhu MY, Ordway GA and Regunathan S. 2006. Expression of arginine decarboxylase in brain regions and neuronal cells. J. Neurochem. 96:1042-50. Iyo AH, Porter B, Deneris ES and Austin MC. 2005. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse 57:223-228.

	Beata Karolewicz, PhD (Psychiatry) Assistant Professor The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Division of Neurobiology and Behavior Research Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5896 FAX: 601-984-5899 E-Mail: bkarolewicz@psychiatry.umsmed.edu
Research Interest: My current research is focused on the involvement of glutamate system in the neuropathology of major depression and suicide. Research projects utilize a variety of biochemical and molecular techniques to investigate protein and gene expression of various glutamate-related receptors, enzymes, and transporters in human postmortem brain specimens. Recent Publications: Karolewicz B, Szebeni K, Gilmore T, Maciag D, Stockmeier CA, Ordway GA. Elevated levels of NR2A and PSD-95 in lateral amygdala in depression. Int J Neuropsychopharmacology 2008. Jun 23:1-11 [Epub ahead of print] Karolewicz B, Johnson L, Szebeni K, Stockmeier CA, Ordway GA: Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. J Psychiatric Research 2008, 42, 348-355

	Tangeng Ma, Ph.D. (Pharmacology) Assistant Professor of Pharmacology and Toxicology The University of Mississippi Medical Center Department of Pharmacology and Toxicology Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1698 FAX: 601-984-1637 E-Mail: tma@pharmacology.umsmed.edu
Research Description: The goal of my research is to understand the neurochemical mechanisms responsible for drugs of abuse and neurotoxicants. A variety of experimental techniques are used in my research, including animal behavioral tests, animal surgery and neurochemical analyses by biochemical, molecular biological and histochemical methods. Recent Publications: Chiu CT, Ma T, Ho IK (2006) Methamphetamine-induced behavioral sensitization in mice: alterations in m-opioid receptor. J. Biomed. Sci. 13:797-811. Tien LT, Ho IK, Loh HH, Ma T (2007) Role of m-opioid receptor in modulation of preproenkephalin mRNA expression and opioid and dopamine receptor binding in methamphetamine-sensitized mice. J. Neurosci. Res. 85:673-680.

	Jose Javier Miguel-Hidalgo, Ph.D. (Psychiatry) Assistant Professor of Psychiatry The University of Mississippi Medical Center Department of Psychiatry 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 FAX: 601-984-5899 E-Mail: jmiguel-hidalgo@psychiatry.umsmed.edu
Research Description: My research focuses on the neurobiology of alcoholism with an especial emphasis on the role of glial cells in the vulnerability and maintenanace of alcohol dependence. This research uses animal models of alcohol preference and human postmortem tissue and applies immunohistochemical, biochemical and pharmacological methods to the study of changes in morphology, cell proliferation and the expression of proteins related with crucial functions mediated by glia such as glutamate transport. Recent Publications: Miguel-Hidalgo, J.J. (2006) Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats. Alcohol and Alcoholism 41(4):379-385. Miguel-Hidalgo, J.J., Overholser J.C., Meltzer, H.Y., Stockmeier, C.A. and Rajkowska, G. (2006) Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship to suicide and duration of alcohol dependence. Alcoholism Clinical and Experimental Research 30(11):1845-1855

	Kenneth E. Oswalt, M.D. (Anesthesiology) Assistant Professor of Anesthesiology The University of Mississippi Medical Center Department of Anesthesiology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5911 Fax: E-mail: koswalt@anesthesia.umsmed.edu

	Xiaoming Ou, Ph.D. (Psychiatry) Assistant Professor of Psychiatry The University of Mississippi Medical Center Department of Psychiatry 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-5898 FAX: 601-984-5899 E-Mail: xou@psychiatry.umsmed.edu
Research Description: Dr. Ou focuses on the studey of regulation and function of several proteins that are implicated in psychiatric/neurodegenerative disorders and alcohol abuse. For example, these proteins are monamine oxidase ( the enzymne for degradation of neurotransmitters) and transcription factors which regulate the expression of monamine oxidase. Recent Publications: Ou XM, Chen K and Shih JC. Glucorcoticoid and Androgen Activation of Monoamine oxidase A are Regulated by R1 and Sp1. J Biol Chem. 2006 Jul 28;281(30):21512-25. Ou XM, Chen K and Shih JC. Monoamine Oxidase A and repressor R1 are involved in apoptotic signalling pathway. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10923-8.

	Ujjwal K. Rout, MPhil, Ph.D. (Surgery) Assistant Professor and Director of Pediatric Surgery Research Labs University of Mississippi Medical Center Department of Surgery Center for Psychiatric Neuroscience Clinical Sciences Building 2500 North State Street Jackson, Mssissippi 39216-4505 Phone: 601-815-5193 Fax: 601-815-5292 E-Mail: urout@surgery.umsmed.edu
Research Description: Neurodevelopmental Disorders: The Feto-placental mechanisms Recent Publications: Rout UK (2006) Valproate, thalidomide and ethyl alcohol alter the migration of HTR-8/SVneo cells. Bio Med Central: Reproductive Biology and Endocrinology. 4:44. Rout UK and Dhossche DM (2008) A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies. Medical Hypothesis, 71:218-221

	Laura Stoppelbein, Ph.D. (Psychiatry) Assistant Professor of Psychiatry and Human Behavior The University of Mississippi Medical Center Department of Psychiatry and Human Behavior Center for Psychiatric Neuroscience 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-815-1793 FAX: 601-815-1514 E-Mail: lstoppelbein@psychiatry.umsmed.edu


	Jun Ming Wang, Ph.D. (Pathology) Assistant Professor of Pathology Assistant Professor of Pharmacology & Toxicology Assistant Professor of Psychiatry & Human Behavior The University of Mississippi Medical Center Department of Pathology 2500 North State Street Jackson, Mississippi 39216-4505 Phone: 601-984-1570 FAX: 601-984-1531 E-Mail: jwang@pathology.umsmed.edu
Research Interests: The major focus of my reserach is to investigate the impact of neurosteroids on prevention of neurodegenerative diseases, such as Alzhiermer's disease and menopausal depression, and on regulation of risk factors of these diseases by monitoring the neurogenesis and neuroprotection. Animal models of Alzheimer's disase and the molecular biology approaches are used in our studies. Recent Publications: Wang JM, Liu L, Brinton RD. Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway. Endocrinology. 2008 149(1):208-218 Wang JM, Irwin RW, Brinton RD. Activation of Estrogen Receptor α Increases and Estrogen Receptor β Decreases Apolipoprotein E Expression in Hippocampus In Vitro and In Vivo. Proc Natl Acad Sci U S A. 2006, 103:16983-16988.
PARTICIPATING DEPARTMENTS
Anatomy (D. Haines) Anesthesiology (C. Brunson) Biochemistry (D. Sittman, interim chair) Medicine (R. De Shazo) Neurology (H. Uschmann) Otolaryngology and Communicative Sciences (S. Stringer) Ob-Gyn (B. Cowan) Pathology (S. Bigler) Pediatrics (O. Evans) Pharmacology (J. Farley, interim chair) Physiology (J. Hall) Psychiatry & Human Behavior (G. Norquist) School of Nursing (K. Bender) Surgery